Thionyl Chloride → 2-Chloro-2-oxoethyl 4'-chlorobiphenyl-4-sulfonate

HRID 2422925

Reaktionsgleichung

Reaktionsgleichung von HRID 2422925
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([S:14]([O:17][CH2:18][C:19]([OH:21])=O)(=[O:16])=[O:15])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.S(Cl)([Cl:24])=O>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([S:14]([O:17][CH2:18][C:19]([Cl:24])=[O:21])(=[O:16])=[O:15])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1

Komponenten

3

Edukt 2

HCID 24386Thionyl ChlorideHCID 86628700HCID 86628700, Verbindung

Produkt 1

HCID 866287022-Chloro-2-oxoethyl 4'-chlorobiphenyl-4-sulfonate

Versuchsvorschrift

A mixture of acid 13 (100 mg, 0.306 mmol) and thionyl chloride (1 ml) was heated at reflux for 1.5 h. The excess thionyl chloride was removed in vacuo and the resulting pale yellow/white solid dried under high vacuum at 50° C. for 1.5 h. The product acid chloride 14 was used without further purification.

Aufarbeitung

  1. temperaturewas heated
  2. temperatureat reflux for 1.5 h
  3. customThe excess thionyl chloride was removed in vacuo
  4. customthe resulting pale yellow/white solid dried under high vacuum at 50° C. for 1.5 h
  5. customThe product acid chloride 14 was used without further purification

Quellen und Nachweise

ORD-Eintrag
ord-d8e1d267abee4aeba70658dc436a7c38
Quelldatensatz
uspto-grants-2011_06
Patentnummer
US07960434B2

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