Trifluoroacetic acid → 3-(chlorosulfonyl)-5-fluorobenzoic acid

HRID 2423241Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2423241
FC(F)(F)C(O)=O.[Cl:8][S:9]([C:12]1[CH:13]=[C:14]([CH:25]=[C:26]([F:28])[CH:27]=1)[C:15]([O:17]CC1C=CC=CC=1)=[O:16])(=[O:11])=[O:10]>>[Cl:8][S:9]([C:12]1[CH:13]=[C:14]([CH:25]=[C:26]([F:28])[CH:27]=1)[C:15]([OH:17])=[O:16])(=[O:10])=[O:11]

Komponenten

3

Edukt 2

HCID 6422Trifluoroacetic acidHCID 86632597HCID 86632597, Verbindung

Produkt 1

HCID 37487043-(chlorosulfonyl)-5-fluorobenzoic acidAusbeute 82,1 %

Versuchsvorschrift

A trifluoroacetic acid (18 mL) solution of benzyl 3-(chlorosulfonyl)-5-fluorobenzoate (2.30 g) was stirred at 60° C. for 18 hours. The oily substance floating on the liquid surface was removed, and the solution part was decanted and evaporated under reduced pressure. Hexane was added to the residue, then this was sonicated for 10 minutes. The resulting solid was collected by filtration to obtain 3-(chlorosulfonyl)-5-fluorobenzoic acid (1.37 g). EI: 238

Aufarbeitung

  1. customwas removed
  2. customthe solution part was decanted
  3. customevaporated under reduced pressure
  4. additionHexane was added to the residue
  5. customthis was sonicated for 10 minutes
  6. filtrationThe resulting solid was collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-1918c54b18684f078d51ca859cc9e109
Quelldatensatz
uspto-grants-2011_06
Patentnummer
US07960562B2

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