4-Fluorobenzonitrile → 4-(1-Azabicyclo[2.2.2]oct-4-ylmethoxy)benzaldehyde

HRID 2423567Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2423567
N12CCC(C[OH:10])(CC1)CC2.FC1C=CC(C#N)=CC=1.[N:20]12[CH2:27][CH2:26][C:23]([CH2:28][O:29][C:30]3[CH:37]=[CH:36][C:33]([C:34]#N)=[CH:32][CH:31]=3)([CH2:24][CH2:25]1)[CH2:22][CH2:21]2>>[N:20]12[CH2:27][CH2:26][C:23]([CH2:28][O:29][C:30]3[CH:37]=[CH:36][C:33]([CH:34]=[O:10])=[CH:32][CH:31]=3)([CH2:24][CH2:25]1)[CH2:22][CH2:21]2

Komponenten

4

Edukt 3

HCID 145174-FluorobenzonitrileHCID 1413111-Azabicyclo(2.2.2)octane-4-methanolHCID 666269004-(1-Azabicyclo[2.2.2]oct-4-ylmethoxy)benzonitrile

Produkt 1

HCID 579343134-(1-Azabicyclo[2.2.2]oct-4-ylmethoxy)benzaldehyde

Versuchsvorschrift

Synthesized from (1-azabicyclo[2.2.2]oct-4-yl)methanol and 4-fluorobenzonitrile according to an analogous synthetic method to Preparation Example 15, 4-(1-azabicyclo[2.2.2]oct-4-ylmethoxy)benzonitrile (200 mg) was used according to an analogous synthetic method to Preparation Example 16 to provide the title compound (120 mg).

Aufarbeitung

  1. customwas used according to an analogous synthetic method to Preparation Example 16

Quellen und Nachweise

ORD-Eintrag
ord-dc02b8bf27da4e2db2bb069fd0af4471
Quelldatensatz
uspto-grants-2011_06
Patentnummer
US07960412B2

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