4-Piperidinol, 1-methyl- → HCID 23087228, Verbindung

HRID 2423573Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2423573
[OH:1]C1CCN(C)CC1.FC1C=C(C=CC=1F)C#N.[F:19][C:20]1[CH:21]=[C:22]([CH:25]=[CH:26][C:27]=1[O:28][CH:29]1[CH2:34][CH2:33][N:32]([CH3:35])[CH2:31][CH2:30]1)[C:23]#N>>[F:19][C:20]1[CH:21]=[C:22]([CH:25]=[CH:26][C:27]=1[O:28][CH:29]1[CH2:34][CH2:33][N:32]([CH3:35])[CH2:31][CH2:30]1)[CH:23]=[O:1]

Komponenten

4

Edukt 3

HCID 660484-Piperidinol, 1-methyl-HCID 5872033,4-DifluorobenzonitrileHCID 230874123-Fluoro-4-(1-methylpiperidin-4-yloxy)benzonitrile

Produkt 1

HCID 23087228HCID 23087228, Verbindung

Versuchsvorschrift

Synthesized from 4-hydroxy-1-methylpiperidine and 3,4-difluorobenzonitrile according to an analogous synthetic method to Preparation Example 15, 3-fluoro-4-(1-methylpiperidin-4-yloxy)benzonitrile (1.1 g) was used according to an analogous synthetic method to Preparation Example 16 to provide the title compound (1.1 g).

Aufarbeitung

  1. customwas used according to an analogous synthetic method to Preparation Example 16

Quellen und Nachweise

ORD-Eintrag
ord-7da41b010ebd47aab4379e8fc531c776
Quelldatensatz
uspto-grants-2011_06
Patentnummer
US07960412B2

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