N-(2-chloroethyl)perhydroazepine hydrochloride → 1-{2-{4-[5-Methoxy-2-(6-methoxynaphthalen-2-yl)benzyl]phenoxy}ethyl}azepane

HRID 2423600Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2423600
OC1C=CC(C(C2C=C(OC)C=CC=2C2C=CC3C(=CC=C(OC)C=3)C=2)=O)=CC=1.Cl.ClCCN1CCCCCC1.[N:41]1([CH2:48][CH2:49][O:50][C:51]2[CH:56]=[CH:55][C:54]([C:57]([C:59]3[CH:64]=[C:63]([O:65][CH3:66])[CH:62]=[CH:61][C:60]=3[C:67]3[CH:76]=[CH:75][C:74]4[C:69](=[CH:70][CH:71]=[C:72]([O:77][CH3:78])[CH:73]=4)[CH:68]=3)=O)=[CH:53][CH:52]=2)[CH2:47][CH2:46][CH2:45][CH2:44][CH2:43][CH2:42]1>>[CH3:66][O:65][C:63]1[CH:62]=[CH:61][C:60]([C:67]2[CH:76]=[CH:75][C:74]3[C:69](=[CH:70][CH:71]=[C:72]([O:77][CH3:78])[CH:73]=3)[CH:68]=2)=[C:59]([CH:64]=1)[CH2:57][C:54]1[CH:55]=[CH:56][C:51]([O:50][CH2:49][CH2:48][N:41]2[CH2:42][CH2:43][CH2:44][CH2:45][CH2:46][CH2:47]2)=[CH:52][CH:53]=1

Komponenten

4

Edukt 3

HCID 24188283N-(2-chloroethyl)perhydroazepine hydrochlorideHCID 57933864(4-Hydroxyphenyl)[5-methoxy-2-(6-methoxynaphthalen-2-yl)phenyl]methanoneHCID 66626326[4-(2-Azepan-1-ylethoxy)phenyl][5-methoxy-2-(6-methoxynaphthalen-2-yl)phenyl]methanone

Produkt 1

HCID 666277861-{2-{4-[5-Methoxy-2-(6-methoxynaphthalen-2-yl)benzyl]phenoxy}ethyl}azepaneAusbeute 72 %

Versuchsvorschrift

Synthesized from (4-hydroxyphenyl)[5-methoxy-2-(6-methoxynaphthalen-2-yl)phenyl]methanone and 1-(2-chloroethyl)azepane hydrochloride according to an analogous synthetic method to Preparation Example 40, [4-(2-azepan-1-ylethoxy)phenyl][5-methoxy-2-(6-methoxynaphthalen-2-yl)phenyl]methanone (1.0 g) was used according to an analogous synthetic method to Example 337 described below to provide 1-{2-{4-[5-methoxy-2-(6-methoxynaphthalen-2-yl)benzyl]phenoxy}ethyl}azepane (700 mg). This compound (421 mg) was used according to an analogous synthetic method to Example 111 described below to provide the title compound (105 mg).

Quellen und Nachweise

ORD-Eintrag
ord-1f746bc4f1db40029f16a7570b467534
Quelldatensatz
uspto-grants-2011_06
Patentnummer
US07960412B2

Notizen zur Reaktion

Wird geladen…