Pyrrolidine → Ethyl[5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl](2-pyrrolidin-1-ylethyl)amine

HRID 2423640Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2423640
ClCC(N(CC)C1C=C(OC)C=CC=1C1CCC2C(=CC=C(OC)C=2)C1)=O.N1CCCC1.[CH2:33]([N:35]([C:44]1[CH:49]=[C:48]([O:50][CH3:51])[CH:47]=[CH:46][C:45]=1[CH:52]1[CH2:61][CH2:60][C:59]2[C:54](=[CH:55][CH:56]=[C:57]([O:62][CH3:63])[CH:58]=2)[CH2:53]1)[C:36](=O)[CH2:37][N:38]1[CH2:42][CH2:41][CH2:40][CH2:39]1)[CH3:34]>>[CH2:33]([N:35]([C:44]1[CH:49]=[C:48]([O:50][CH3:51])[CH:47]=[CH:46][C:45]=1[CH:52]1[CH2:61][CH2:60][C:59]2[C:54](=[CH:55][CH:56]=[C:57]([O:62][CH3:63])[CH:58]=2)[CH2:53]1)[CH2:36][CH2:37][N:38]1[CH2:39][CH2:40][CH2:41][CH2:42]1)[CH3:34]

Komponenten

4

Edukt 3

HCID 31268PyrrolidineHCID 579341032-chloro-N-ethyl-N-[5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]acetamideHCID 66626207N-ethyl-N-[5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]-2-pyrrolidin-1-ylacetamide

Produkt 1

HCID 66626973Ethyl[5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl](2-pyrrolidin-1-ylethyl)amineAusbeute 83,4 %

Versuchsvorschrift

Synthesized from 2-chloro-N-ethyl-N-[5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]acetamide and pyrrolidine according to an analogous synthetic method to Preparation Example 89, N-ethyl-N-[5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]-2-pyrrolidin-1-ylacetamide (119 mg) was used according to an analogous synthetic method to Example 337 described below to provide ethyl [5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl](2-pyrrolidin-1-ylethyl)amine (96 mg). This compound (95 mg) was used according to an analogous synthetic method to Example 111 described below to provide the title compound (92 mg).

Quellen und Nachweise

ORD-Eintrag
ord-500bcb943b6e4b148fcd939ea95b624c
Quelldatensatz
uspto-grants-2011_06
Patentnummer
US07960412B2

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