2-[6-(tert-Butyldimethylsilyloxy)-1,2,3,4-tetrahydronaphthalen-2-yl]-5-methoxyphenylamine → [4-(2-Azepan-1-ylethoxy)benzyl]{2-[6-(tert-butyldimethylsilyloxy)-1,2,3,4-tetrahydronaphthalen-2-yl]-5-methoxyphenyl}ethylamine

HRID 2423745Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2423745
[Si:1]([O:8][C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][CH:18]=1)[CH2:15][CH:14]([C:19]1[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[CH:21][C:20]=1N)[CH2:13][CH2:12]2)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].Cl.N1(CCOC2C=CC(C(Cl)=O)=CC=2)CCCCCC1.[N:48]1([CH2:55][CH2:56][O:57][C:58]2[CH:91]=[CH:90][C:61]([CH2:62][NH:63][C:64]3C=C(OC)C=C[C:65]=3C3CCC4C(=CC=C(O[Si](C(C)(C)C)(C)C)C=4)C3)=[CH:60][CH:59]=2)[CH2:54][CH2:53][CH2:52][CH2:51][CH2:50][CH2:49]1>>[N:48]1([CH2:55][CH2:56][O:57][C:58]2[CH:59]=[CH:60][C:61]([CH2:62][NH:63][CH2:64][CH2:65][C:20]3[CH:21]=[C:22]([O:25][CH3:26])[CH:23]=[CH:24][C:19]=3[CH:14]3[CH2:13][CH2:12][C:11]4[C:16](=[CH:17][CH:18]=[C:9]([O:8][Si:1]([C:4]([CH3:7])([CH3:5])[CH3:6])([CH3:3])[CH3:2])[CH:10]=4)[CH2:15]3)=[CH:90][CH:91]=2)[CH2:49][CH2:50][CH2:51][CH2:52][CH2:53][CH2:54]1

Komponenten

4

Edukt 3

HCID 579340442-[6-(tert-Butyldimethylsilyloxy)-1,2,3,4-tetrahydronaphthalen-2-yl]-5-methoxyphenylamineHCID 66627022[4-(2-Azepan-1-ylethoxy)benzyl]{2-[6-(tert-butyldimethylsilyloxy)-1,2,3,4-tetrahydronaphthalen-2-yl]-5-methoxyphenyl}amineHCID 866052404-(2-Azepan-1-ylethoxy)benzoyl chloride hydrochloride

Produkt 1

HCID 66627675[4-(2-Azepan-1-ylethoxy)benzyl]{2-[6-(tert-butyldimethylsilyloxy)-1,2,3,4-tetrahydronaphthalen-2-yl]-5-methoxyphenyl}ethylamine

Versuchsvorschrift

Synthesized from 2-[6-(tert-butyldimethylsilyloxy)-1,2,3,4-tetrahydronaphthalen-2-yl]-5-methoxyphenylamine and 4-(2-azepan-1-ylethoxy)benzoyl chloride hydrochloride according to an analogous synthetic method to Example 152, [4-(2-azepan-1-ylethoxy)benzyl]{2-[6-(tert-butyldimethylsilyloxy)-1,2,3,4-tetrahydronaphthalen-2-yl]-5-methoxyphenyl}amine (448 mg) was used according to an analogous synthetic method to Example 36 to provide [4-(2-azepan-1-ylethoxy)benzyl]{2-[6-(tert-butyldimethylsilyloxy)-1,2,3,4-tetrahydronaphthalen-2-yl]-5-methoxyphenyl}ethylamine (392 mg). This compound (390 mg) was used according to an analogous synthetic method to Example 325 described below to provide the title compound (254 mg).

Quellen und Nachweise

ORD-Eintrag
ord-7896a5dc058b495d898d847bbe585940
Quelldatensatz
uspto-grants-2011_06
Patentnummer
US07960412B2

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