(2,3,4-Trimethoxy-6-methylphenyl)(3-chloro-5-trifluoromethyl-4-pyridyl)methanol → 4-(2,3,4-Trimethoxy-6-methylbenzoyl)-3-chloro-5-trifluoromethylpyridine

HRID 242433Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 242433
[CH3:1][O:2][C:3]1[C:8]([O:9][CH3:10])=[C:7]([O:11][CH3:12])[CH:6]=[C:5]([CH3:13])[C:4]=1[CH:14]([C:16]1[C:21]([C:22]([F:25])([F:24])[F:23])=[CH:20][N:19]=[CH:18][C:17]=1[Cl:26])[OH:15]>[O-2].[O-2].[Mn+4].C1(C)C=CC=CC=1>[CH3:1][O:2][C:3]1[C:8]([O:9][CH3:10])=[C:7]([O:11][CH3:12])[CH:6]=[C:5]([CH3:13])[C:4]=1[C:14]([C:16]1[C:21]([C:22]([F:25])([F:23])[F:24])=[CH:20][N:19]=[CH:18][C:17]=1[Cl:26])=[O:15]

Komponenten

4

Edukt 1

HCID 12151302(2,3,4-Trimethoxy-6-methylphenyl)(3-chloro-5-trifluoromethyl-4-pyridyl)methanol

Produkt 1

HCID 121513034-(2,3,4-Trimethoxy-6-methylbenzoyl)-3-chloro-5-trifluoromethylpyridineAusbeute 94,2 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418406HCID 178418406, VerbindungKatalysatorHCID 1140TolueneLösungsmittel

Versuchsvorschrift

45 g of manganese dioxide was added to a toluene 220 ml solution of 15.9 g (40.6 mmol) of (2,3,4-trimethoxy-6-methylphenyl)(3-chloro-5-trifluoromethyl-4-pyridyl)methanol obtained in Step (b), followed by stirring under reflux with heating for 2 hours. The mixture was subjected to filtration, and the solvent was distilled off under reduced pressure to obtain 14.9 g (yield: 94%) of 4-(2,3,4-trimethoxy-6-methylbenzoyl)-3-chloro-5-trifluoromethylpyridine.

Aufarbeitung

  1. temperatureunder reflux
  2. temperaturewith heating for 2 hours
  3. filtrationThe mixture was subjected to filtration
  4. distillationthe solvent was distilled off under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-13f5736344ca40c98c7109979a16f146
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08653113B2

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