(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-5-methyl-3-(2,4,5-trifluorophenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-1-carboxamide → HCID 46863444, Verbindung

HRID 242459

Reaktionsgleichung

Reaktionsgleichung von HRID 242459
[CH3:1][C:2]([CH3:31])([CH3:30])[C@H:3]([NH:8][C:9]([N:11]1[C:19]2[CH2:18][CH2:17][N:16]([CH3:20])[CH2:15][C:14]=2[C:13]([C:21]2[CH:26]=[C:25]([F:27])[C:24]([F:28])=[CH:23][C:22]=2F)=[N:12]1)=[O:10])[C:4]([NH:6][CH3:7])=[O:5].FC1C=C(C2C3CN(C([O:51][C:52](C)([CH3:54])[CH3:53])=O)CCC=3NN=2)C=CC=1F>>[F:27][C:25]1[CH:26]=[C:21]([C:13]2[C:14]3[CH2:15][N:16]([CH3:20])[CH2:17][CH2:18][C:19]=3[N:11]([C:9]([NH:8][C@@H:3]([C:2]([CH3:30])([CH3:31])[CH3:1])[C:4]([N:6]3[CH2:7][CH2:54][C@H:52]([OH:51])[CH2:53]3)=[O:5])=[O:10])[N:12]=2)[CH:22]=[CH:23][C:24]=1[F:28]

Komponenten

3

Edukt 2

HCID 46863441(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-5-methyl-3-(2,4,5-trifluorophenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-1-carboxamideHCID 59345327tert-butyl 3-(3,4-difluorophenyl)-6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carboxylate

Produkt 1

HCID 46863444HCID 46863444, Verbindung

Versuchsvorschrift

Compound 47 was prepared according to the procedure described for the synthesis of compound 37 by replacing intermediate 19 with intermediate 15, and replacing tert-leucine methylamide with intermediate 25. LCMS (+ESI) m/z=476.3 [M+H]+.

Quellen und Nachweise

ORD-Eintrag
ord-4d5635156dbc47a98976a3309ff556ac
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08653127B2

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