2,5-Difluorobenzoyl chloride → (S)-3-(2,5-difluorophenyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-5-methyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-1-carboxamide

HRID 242470Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 242470
[CH3:1][C:2]([CH3:31])([CH3:30])[C@H:3]([NH:8][C:9]([N:11]1[C:19]2[CH2:18][CH2:17][N:16]([CH3:20])[CH2:15][C:14]=2[C:13]([C:21]2[CH:26]=[C:25]([F:27])[C:24](F)=[CH:23][C:22]=2[F:29])=[N:12]1)=[O:10])[C:4]([NH:6][CH3:7])=[O:5].FC1C=CC(F)=CC=1C(Cl)=O>>[F:29][C:22]1[CH:23]=[CH:24][C:25]([F:27])=[CH:26][C:21]=1[C:13]1[C:14]2[CH2:15][N:16]([CH3:20])[CH2:17][CH2:18][C:19]=2[N:11]([C:9]([NH:8][C@@H:3]([C:2]([CH3:31])([CH3:30])[CH3:1])[C:4]([NH:6][CH3:7])=[O:5])=[O:10])[N:12]=1

Komponenten

3

Edukt 2

HCID 5880822,5-Difluorobenzoyl chlorideHCID 46863441(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-5-methyl-3-(2,4,5-trifluorophenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-1-carboxamide

Produkt 1

HCID 59345319(S)-3-(2,5-difluorophenyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-5-methyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-1-carboxamide

Versuchsvorschrift

Compound 64 was prepared according to the procedure described for the synthesis of compound 37 by replacing 2,4,5-trifluorobenzoyl chloride with 2,5-difluorobenzoyl chloride in the synthesis of intermediate 19. LCMS (+ESI) m/z=420.2 [M+H]+.

Quellen und Nachweise

ORD-Eintrag
ord-dbc0cb3774a9455daedb4cb87ef047ac
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08653127B2

Notizen zur Reaktion

Wird geladen…