(2S)-2-Amino-3,3-dimethyl-1-butanol → (S)-3-(2,5-difluorophenyl)-N-(1-hydroxy-3,3-dimethylbutan-2-yl)-5-methyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-1-carboxamide

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	(2S)-2-Amino-3,3-dimethyl-1-butanol	HCID 2734079	—
Edukt	(S)-3-(2,5-difluorophenyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-5-methyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-1-carboxamide	HCID 59345319	—
Produkt	(S)-3-(2,5-difluorophenyl)-N-(1-hydroxy-3,3-dimethylbutan-2-yl)-5-methyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-1-carboxamide	HCID 46862675	—

Reaktionsschritte

Compound 66 was prepared according to the procedure described for the synthesis of compound 64 by replacing tert-leucine methylamide with tert-leucinol. LCMS (+ESI) m/z=393.3 [M+H]+.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US08653127B2
Quelldatensatz	uspto-grants-2014_02
ORD ID	ord-e36008064eeb4e7dbd22fcff7646e1d0
Quellennotiz	uspto-grants-2014_02