HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2,4,5-Trifluorobenzoyl chloride → (S)-3-(3,4-difluorophenyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-4-methyl-5,6,7,8-tetrahydropyrazolo[4,3-b]azepine-1(4H)-carboxamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 2,4,5-Trifluorobenzoyl chloride | HCID 145164 | — |
| Edukt | tert-Butyl 4-oxopiperidine-1-carboxylate | HCID 735900 | — |
| Edukt | 3,4-Difluorobenzoyl chloride | HCID 2724519 | — |
| Edukt | tert-Butyl 3-oxoazepane-1-carboxylate | HCID 22831870 | — |
| Edukt | (S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-5-methyl-3-(2,4,5-trifluorophenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-1-carboxamide | HCID 46863441 | — |
| Produkt | (S)-3-(3,4-difluorophenyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-4-methyl-5,6,7,8-tetrahydropyrazolo[4,3-b]azepine-1(4H)-carboxamide | HCID 59345359 | — |
Reaktionsschritte
Compound 69 was prepared according to the procedure described above for the synthesis of compound 37 except that 1-Boc-4-piperidone was replaced with tert-butyl 3-oxoazepane-1-carboxylate and 2,4,5-trifluorobenzoyl-chloride was replaced with 3,4-difluorobenzoylchloride. LCMS (+ESI) m/z=434.2 [M+H]+.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08653127B2 |
| Quelldatensatz | uspto-grants-2014_02 |
| ORD ID | ord-40bdf287a2a14cebb12d18199dcae4fe |
| Quellennotiz | uspto-grants-2014_02 |