4-Chloro-2-fluorobenzoyl chloride → HCID 46830662, Verbindung

HRID 242490

Reaktionsgleichung

Reaktionsgleichung von HRID 242490
[OH:1][CH2:2][CH2:3][NH:4][C:5](=[O:31])[C@@H:6]([NH:11][C:12]([N:14]1[C:18]2[CH2:19][CH2:20][O:21][CH2:22][C:17]=2C(C2C=CC(F)=C(F)C=2)=[N:15]1)=[O:13])[C:7]([CH3:10])([CH3:9])[CH3:8].[Cl:32][C:33]1[CH:41]=[CH:40][C:36]([C:37](Cl)=O)=[C:35]([F:42])[CH:34]=1>>[Cl:32][C:33]1[CH:41]=[CH:40][C:36]([C:37]2[C:19]3[CH2:20][O:21][CH2:22][CH2:17][C:18]=3[N:14]([C:12]([NH:11][C@@H:6]([C:7]([CH3:9])([CH3:10])[CH3:8])[C:5]([NH:4][CH2:3][CH2:2][OH:1])=[O:31])=[O:13])[N:15]=2)=[C:35]([F:42])[CH:34]=1

Komponenten

3

Edukt 2

HCID 27736014-Chloro-2-fluorobenzoyl chlorideHCID 46220523(S)-N-(1-(2-hydroxyethylamino)-3,3-dimethyl-1-oxobutan-2-yl)-3-(3,4-difluorophenyl)-6,7-dihydropyrano[4,3-c]pyrazole-1(4H)-carboxamide

Produkt 1

HCID 46830662HCID 46830662, Verbindung

Versuchsvorschrift

Compound 88 was prepared according to the procedure for the synthesis of compound 36 by replacing 3,4-difluorobenzoyl chloride with 4-chloro-2-fluorobenzoyl chloride. LCMS (+ESI) m/z=453.3 [M+H]+. 1H NMR (CDCl3) δ 7.90 (d, J=9.0 Hz, 1H), 7.67 (t, J=8.1 Hz, 1H), 7.16-7.24 (m, 2H), 6.45 (br, 1H), 4.65 (s, 2H), 4.18 (d, J=9.1 Hz, 1H), 3.94 (t, J=5.6 Hz, 2H), 3.73 (br, 2H), 3.45 (br, 2H), 3.17 (br, 2H), 1.10 (s, 9H). Purity: 98%.

Quellen und Nachweise

ORD-Eintrag
ord-75fab7fabb924f75a9aa15e9a1f6b178
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08653127B2

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