HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
1-(Thiazol-2-yl)piperazine → HCID 46862248, Verbindung
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 1-(Thiazol-2-yl)piperazine | HCID 911806 | — |
| Edukt | (S)-N-(1-(2-cyanoethylamino)-3,3-dimethyl-1-oxobutan-2-yl)-3-(3,4-difluorophenyl)-6,7-dihydropyrano[4,3-c]pyrazole-1(4H)-carboxamide | HCID 46862252 | — |
| Produkt | HCID 46862248 | HCID 46862248 | — |
Reaktionsschritte
Compound 108 was prepared by the procedure described for the synthesis of compound 104 by replacing 2-cyanoethylamine with 2-(piperazin-1-yl)thiazole. LCMS (+ESI) m/z=545.3 [M+H]+. 1H NMR (CDCl3) δ 7.93 (d, J=9.6 Hz, 1H), 7.48-7.52 (m, 1H), 7.30-7.32 (m, 1H), 7.19-7.26 (m, 2H), 6.63 (d, J=3.7 Hz, 1H), 4.87 (d, J=9.6 Hz, 1H), 4.82 (s, 2H), 3.87-3.98 (m, 4H), 3.64-3.81 (m, 3H), 3.45-3.58 (m, 3H), 3.18 (br, 2H), 1.11 (s, 9H).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08653127B2 |
| Quelldatensatz | uspto-grants-2014_02 |
| ORD ID | ord-ed51f6f8257949be9ba9fe135eb41797 |
| Quellennotiz | uspto-grants-2014_02 |