Chlorosulfonic acid → 4'-Bromo-2'-fluorobiphenyl sulfonic acid

HRID 2425135Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2425135
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[C:4]([F:14])[CH:3]=1.Cl[S:16]([OH:19])(=[O:18])=[O:17]>C(Cl)(Cl)Cl>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:13]([S:16]([OH:19])(=[O:18])=[O:17])=[CH:12][CH:11]=[CH:10][CH:9]=2)=[C:4]([F:14])[CH:3]=1

Komponenten

4

Edukt 2

HCID 24638Chlorosulfonic acidHCID 5210634-Bromo-2-fluoro-1,1'-biphenyl

Produkt 1

HCID 866202994'-Bromo-2'-fluorobiphenyl sulfonic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

4′-Bromo-2′-fluorobiphenyl (5 g) was dissolved in chloroform (80 mL) at room temperature. Chlorosulfonic acid (5 g) was added dropwise and a precipitate appeared soon after addition was complete. Stirring was continued for a further 4 hours, after which the solid was collected by filtration. Further crops of crystals were collected from the filtrate. The solid was washed with cold chloroform and the washings also allowed to crystallise.

Aufarbeitung

  1. additionafter addition
  2. filtrationafter which the solid was collected by filtration
  3. customFurther crops of crystals were collected from the filtrate
  4. washThe solid was washed with cold chloroform
  5. customto crystallise

Quellen und Nachweise

ORD-Eintrag
ord-62303b5b96bc465fb62fa88326c501f0
Quelldatensatz
uspto-grants-2011_06
Patentnummer
US07964643B2

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