3-(N-tert-Butoxycarbonyl-N-methylamino)pyrrolidine → Hydrochloric Acid

HRID 2425412

Reaktionsgleichung

Reaktionsgleichung von HRID 2425412
C(OC([N:8]([CH:10]1[CH2:14][CH2:13][N:12]([S:15]([C:18]2[C:19]3[C:20]([Cl:29])=[CH:21][N:22]=[C:23]([Cl:28])[C:24]=3[CH:25]=[CH:26][CH:27]=2)(=[O:17])=[O:16])[CH2:11]1)[CH3:9])=O)(C)(C)C.ClC1C2C=CC=C(S(Cl)(=O)=[O:42])C=2C(Cl)=CN=1.C(OC(N(C1CCNC1)C)=O)(C)(C)C.ClC1C2C=CC=C(S(Cl)(=O)=O)C=2C(Br)=CN=1.C(OC(N([C@H]1CCNC1)C)=O)(C)(C)C>>[OH:42][C:23]1[C:24]2[CH:25]=[CH:26][CH:27]=[C:18]([S:15]([N:12]3[CH2:13][CH2:14][CH:10]([NH:8][CH3:9])[CH2:11]3)(=[O:16])=[O:17])[C:19]=2[C:20]([Cl:29])=[CH:21][N:22]=1.[ClH:28]

Komponenten

7

Edukt 5

HCID 27614043-(N-tert-Butoxycarbonyl-N-methylamino)pyrrolidineHCID 7171888(S)-Methyl-pyrrolidin-3-yl-carbamic acid tert-butyl esterHCID 768514895-Isoquinolinesulfonyl chloride,1,4-dichloro-HCID 768514905-Isoquinolinesulfonyl chloride,4-bromo-1-chloro-HCID 866278123-[N-(tert-Butoxycarbonyl)-N-methylamino]-1-(1,4-dichloro-5-isoquinolinesulfonyl)pyrrolidine2×

Produkt 2

HCID 313Hydrochloric AcidHCID 178482264HCID 178482264, Verbindung

Versuchsvorschrift

3-[N-(tert-Butoxycarbonyl)-N-methylamino]-1-(1,4-dichloro-5-isoquinolinesulfonyl)pyrrolidine (Intermediate 25) can be prepared by using 1,4-dichloro-5-isoquinolinesulfonyl chloride and 3-[N-(tert-butoxycarbonyl)-N-methylamino]pyrrolidine in the method of Example 35-1, Step A instead of 1-chloro-4-bromo-5-isoquinolinesulfonyl chloride and (S)-3-[N-(tert-butoxycarbonyl)-N-methylamino]pyrrolidine, respectively, and then used in the method of Example 35-1, Step B in a similar manner to obtain the title compound as hydrochloride.

Quellen und Nachweise

ORD-Eintrag
ord-decfa694efea455baa131f5a484d72a8
Quelldatensatz
uspto-grants-2011_06
Patentnummer
US07964613B2

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