HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
tert-Butyl methyl((3R)-pyrrolidin-3-yl)carbamate → Hydrochloric Acid
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | tert-Butyl methyl((3R)-pyrrolidin-3-yl)carbamate | HCID 7019173 | — |
| Edukt | (S)-Methyl-pyrrolidin-3-yl-carbamic acid tert-butyl ester | HCID 7171888 | — |
| Edukt | 5-Isoquinolinesulfonyl chloride,4-bromo-1-chloro- | HCID 76851490 | — |
| Edukt | (R)-3-[N-(tert-Butoxycarbonyl)-N-methylamino]-1-(1-chloro-4-fluoro-5-isoquinolinesulfonyl)pyrrolidine | HCID 86613860 | — |
| Edukt | 1-Chloro-4-fluoro-5-isoquinolinesulfonyl chloride | HCID 86613861 | — |
| Produkt | Hydrochloric Acid | HCID 313 | — |
| Produkt | HCID 178484870 | HCID 178484870 | — |
Reaktionsschritte
(R)-3-[N-(tert-Butoxycarbonyl)-N-methylamino]-1-(1-chloro-4-fluoro-5-isoquinolinesulfonyl)pyrrolidine (Intermediate 27b) can be prepared by using 1-chloro-4-fluoro-5-isoquinolinesulfonyl chloride and (R)-3-[N-(tert-butoxycarbonyl)-N-methylamino]pyrrolidine in the method of Example 35-1, Step A instead of 1-chloro-4-bromo-5-isoquinolinesulfonyl chloride and (S)-3-[N-(tert-butoxycarbonyl)-N-methylamino]pyrrolidine, respectively, and then used in the method of Example 35-1, Step B in a similar manner to obtain the title compound as hydrochloride.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07964613B2 |
| Quelldatensatz | uspto-grants-2011_06 |
| ORD ID | ord-19333d809e3f43df95f436cdb6ae2e71 |
| Quellennotiz | uspto-grants-2011_06 |