HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
(3S)-(-)-3-(tert-Butoxycarbonylamino)pyrrolidine → 4-[1-(tert-Butoxycarbonylamino)ethyl]-1-(4-chloro-5-isoquinolinesulfonyl)piperidine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | (3S)-(-)-3-(tert-Butoxycarbonylamino)pyrrolidine | HCID 1514396 | — |
| Edukt | 4-Bromo-5-isoquinolinesulfonyl chloride | HCID 14580058 | — |
| Edukt | 4-Chloroisoquinoline-5-sulfonyl chloride | HCID 22121908 | — |
| Edukt | tert-butyl N-[1-(piperidin-4-yl)ethyl]carbamate | HCID 43523185 | — |
| Edukt | HCID 178418361 | HCID 178418361 | — |
| Produkt | 4-[1-(tert-Butoxycarbonylamino)ethyl]-1-(4-chloro-5-isoquinolinesulfonyl)piperidine | HCID 67244329 | — |
Reaktionsschritte
4-Chloro-5-isoquinolinesulfonyl chloride obtained in Reference Example 7 (131 mg) and 4-[1-(tert-butoxycarbonylamino)ethyl]piperidine (134 mg) prepared according to the method described in WO05/080394 were used in the method of Example 1-1, Step A instead of 4-bromo-5-isoquinolinesulfonyl chloride and (S)-3-(tert-butoxycarbonylamino)pyrrolidine, respectively, to obtain the title compound (211 mg).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07964613B2 |
| Quelldatensatz | uspto-grants-2011_06 |
| ORD ID | ord-24ed6022fcfb4fcb841b35275abe4f07 |
| Quellennotiz | uspto-grants-2011_06 |