Sodium Hydroxide → 2-(1-Methylcyclopropyl)quinoline-6-carboxylic acid

HRID 2425568Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2425568
C[O:2][C:3]([C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][CH:14]=1)[N:11]=[C:10]([C:15]1([CH3:18])[CH2:17][CH2:16]1)[CH:9]=[CH:8]2)=[O:4].[OH-].[Na+]>CO>[CH3:18][C:15]1([C:10]2[CH:9]=[CH:8][C:7]3[C:12](=[CH:13][CH:14]=[C:5]([C:3]([OH:4])=[O:2])[CH:6]=3)[N:11]=2)[CH2:16][CH2:17]1

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 66636963Methyl 2-(1-methylcyclopropyl)quinoline-6-carboxylate

Produkt 1

HCID 595441812-(1-Methylcyclopropyl)quinoline-6-carboxylic acidAusbeute 84 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of Methyl-2-(1-methylcyclopropyl)quinoline-6-carboxylate (225 mg, 0.93 mmol) and 2M sodium hydroxide solution (2 ml. 4 mmol) in methanol (10 ml) was heated at 60° C. for 2 hours. After the solvent was evaporated in vacuo, the residue was dissolved in water. The aqueous solution was neutralized with 2M hydrochloric acid solution (2 ml) and the precipitated white solid was extracted with ethyl acetate (×3). The combined solution was washed with brine, dried over sodium sulfate and concentrated in vacuo to give crude white solid, which was recrystallized from ethyl acetate and hexane to furnish the title compound (177 mg, 84%) as a white solid. MS (ESI): m/z 228.15 [M+H]+, 226.13 [M−H]−.

Aufarbeitung

  1. customAfter the solvent was evaporated in vacuo
  2. dissolutionthe residue was dissolved in water
  3. extractionthe precipitated white solid was extracted with ethyl acetate (×3)
  4. washThe combined solution was washed with brine
  5. dry with materialdried over sodium sulfate
  6. concentrationconcentrated in vacuo
  7. customto give crude white solid, which
  8. customwas recrystallized from ethyl acetate and hexane

Quellen und Nachweise

ORD-Eintrag
ord-6e22d231ef704ab8b95983c4d7d12f77
Quelldatensatz
uspto-grants-2011_06
Patentnummer
US07964732B2

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