Ethanol → Ethyl 2-methoxyimino-5-methyl-4-oxohexanoate

HRID 2427061Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2427061
[OH:1][C:2]([CH:11]([CH3:13])[CH3:12])=[CH:3][C:4](=O)[C:5]([O:7][CH2:8][CH3:9])=[O:6].Cl.[CH3:15][O:16][NH2:17].C(O)C>C(OCC)(=O)C>[CH3:15][O:16][N:17]=[C:4]([CH2:3][C:2](=[O:1])[CH:11]([CH3:13])[CH3:12])[C:5]([O:7][CH2:8][CH3:9])=[O:6]

Komponenten

5

Edukt 3

HCID 702EthanolHCID 521874O-Methylhydroxylamine hydrochlorideHCID 178473097HCID 178473097, Verbindung

Produkt 1

HCID 86632548Ethyl 2-methoxyimino-5-methyl-4-oxohexanoateAusbeute 92 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

A mixture of 5.0 g of ethyl 4-hydroxy-5-methyl-2-oxo-3-hexenoate, 2.46 g of O-methylhydroxylamine hydrochloride and 10 ml of ethanol was stirred at room temperature for 6 hours. After ethyl acetate was poured into the reaction mixture, the organic layer was washed with water and an aqueous saturated sodium chloride solution, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to obtain 5.32 g of ethyl 2-methoxyimino-5-methyl-4-oxohexanoate of the formula:

Aufarbeitung

  1. washthe organic layer was washed with water
  2. dry with materialan aqueous saturated sodium chloride solution, dried over anhydrous magnesium sulfate
  3. concentrationconcentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-a923c9a1a1ed4a699366518304057969
Quelldatensatz
uspto-grants-2011_06
Patentnummer
US07968573B2

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