Sodium Hydroxide → HCID 57949645, Verbindung

HRID 2427495Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2427495
[Br:1][C:2]1[CH:9]=[C:8]([CH3:10])[C:5]([C:6]#[N:7])=[C:4]([O:11][CH3:12])[CH:3]=1.[OH-:13].[Na+]>CO>[Br:1][C:2]1[CH:9]=[C:8]([CH3:10])[C:5]([C:6]([NH2:7])=[O:13])=[C:4]([O:11][CH3:12])[CH:3]=1

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 454803844-bromo-2-methoxy-6-methylbenzonitrile

Produkt 1

HCID 57949645HCID 57949645, VerbindungAusbeute 90 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

4-Bromo-2-methoxy-6-methyl benzonitrile (7.3 g, 32.4 mmol) was stirred in MeOH (100 mL) and 5N NaOH (100 mL) at 100° C. for 12 hours. The reaction was cooled to room temperature and the methanol was removed under reduced pressure. The reaction mixture was extracted with CH2Cl2 and the solvent was removed under reduced pressure to yield the product (7.13 g, 90%). 1H NMR (300 MHz, CDCl3): δ 7.03 (d, 1H), 6.94 (d, 1H), 5.83 (br s, 2H), 3.85 (s, 3H), 2.39 (s, 3H).

Aufarbeitung

  1. customthe methanol was removed under reduced pressure
  2. extractionThe reaction mixture was extracted with CH2Cl2
  3. customthe solvent was removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-d43eeb57947f49f49ffdc57d393ffec6
Quelldatensatz
uspto-grants-2011_06
Patentnummer
US07968570B2

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