Chlorosulfonic acid → 5-fluoro-4-hydroxy-2-methylbenzenesulfonyl Chloride

HRID 243614Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 243614
[Cl:1][S:2]([OH:5])(=O)=[O:3].[F:6][C:7]1[CH:12]=[CH:11][C:10]([CH3:13])=[CH:9][C:8]=1[OH:14]>ClCCl>[F:6][C:7]1[C:8]([OH:14])=[CH:9][C:10]([CH3:13])=[C:11]([S:2]([Cl:1])(=[O:5])=[O:3])[CH:12]=1

Komponenten

4

Edukt 2

HCID 24638Chlorosulfonic acidHCID 182387Phenol, 2-fluoro-5-methyl-

Produkt 1

HCID 847898185-fluoro-4-hydroxy-2-methylbenzenesulfonyl ChlorideAusbeute 7,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of chlorosulfonic acid (1.5 g, 13.3 mmol) dissolved in 10 mL of dichloromethane was added 2-fluoro-5-methylphenol (1.1 g, 8.86 mmol) dropwise. After 10 minutes, the reaction was quenched by adding to ice water. The reaction was extracted with dichloromethane, washed with brine, dried over MgSO4, filtered, and concentrated to give 150 mg (7.5%) of the title compound.

Aufarbeitung

  1. customthe reaction was quenched
  2. additionby adding to ice water
  3. extractionThe reaction was extracted with dichloromethane
  4. washwashed with brine
  5. dry with materialdried over MgSO4
  6. filtrationfiltered
  7. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-9712bed19a3b48b08e5d273d585b8cf2
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08653141B2

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