Trifluoroacetic acid → (3-Methyl-2-oxotetrahydropyrimidin-1(2H)-yl)acetic acid

HRID 243714Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 243714
[CH3:1][N:2]1[CH2:7][CH2:6][CH2:5][N:4]([CH2:8][C:9]([O:11]C(C)(C)C)=[O:10])[C:3]1=[O:16].C(O)(C(F)(F)F)=O>ClCCl>[CH3:1][N:2]1[CH2:7][CH2:6][CH2:5][N:4]([CH2:8][C:9]([OH:11])=[O:10])[C:3]1=[O:16]

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 59011720Tert-butyl(3-methyl-2-oxotetrahydropyrimidin-1(2H)-yl)acetate

Produkt 1

HCID 57907519(3-Methyl-2-oxotetrahydropyrimidin-1(2H)-yl)acetic acidAusbeute 1.012,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of 0.090 g (0.39 mmol) of tert-butyl (3-methyl-2-oxotetrahydropyrimidin-1(2H)-yl)acetate from step B above in 4 mL of anhydrous dichloromethane was added 1 mL of TFA. The resulting mixture was stirred at ambient temperature for 6 h then evaporated to dryness in vacuo to afford the title compound as an off-white gum (0.68 g, 99%). LC-MS: m/z (ES) 173 (MH)+.

Aufarbeitung

  1. customthen evaporated to dryness in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-ced8246261cd48b1b81f4e09c42d593e
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08653260B2

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