3-[1,2,3]Triazol-2-yl-pyridine-2-carboxylic acid → tert-Butyl 5-(3-(2H-1,2,3-triazol-2-yl)picolinoyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate

HRID 243863

Reaktionsgleichung

Reaktionsgleichung von HRID 243863
N1N=C(C2C=CC=CC=2C([N:14]2[CH2:18][CH:17]3[CH2:19][N:20]([C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23])[CH2:21][CH:16]3[CH2:15]2)=O)NC=1.[N:29]1[N:30]([C:34]2[C:35]([C:40]([OH:42])=O)=[N:36][CH:37]=[CH:38][CH:39]=2)[N:31]=[CH:32][CH:33]=1.N1N=C(C2C=CC=CC=2C(O)=O)NC=1>>[N:31]1[N:30]([C:34]2[C:35]([C:40]([N:14]3[CH2:18][CH:17]4[CH2:19][N:20]([C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23])[CH2:21][CH:16]4[CH2:15]3)=[O:42])=[N:36][CH:37]=[CH:38][CH:39]=2)[N:29]=[CH:33][CH:32]=1

Komponenten

4

Edukt 3

HCID 667422883-[1,2,3]Triazol-2-yl-pyridine-2-carboxylic acid2×HCID 178451519HCID 178451519, VerbindungHCID 178524291HCID 178524291, Verbindung

Produkt 1

HCID 86669169tert-Butyl 5-(3-(2H-1,2,3-triazol-2-yl)picolinoyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate

Versuchsvorschrift

tert-Butyl 5-(3-(2H-1,2,3-triazol-2-yl)picolinoyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate was prepared in a manner analogous to Intermediate 59 substituting 3-[1,2,3]triazol-2-yl-pyridine-2-carboxylic acid (Intermediate 72) for 2-(4H-[1,2,4]triazol-3-yl)benzoic acid. MS (ESI) mass calculated for C19H24N6O3, 384.19; m/z found, 385.1.

Quellen und Nachweise

ORD-Eintrag
ord-5823d9291ab342d6bef824dab3c68999
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08653263B2

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