HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 24390Erstellt: 25. Oktober 2026
Piperidine → N-[3-(2,2-dimethylchroman-6-ylmethylene)-2-oxo-2,3-dihydro-1H-indol-6-yl]acetamide
https://huagongshe.com/reaction/24390
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Piperidine | HCID 8082 | — |
| Edukt | 2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-6-carbaldehyde | HCID 1797751 | — |
| Edukt | N-(2-Oxoindolin-6-yl)acetamide | HCID 2749839 | — |
| Lösungsmittel | Water | HCID 962 | — |
| Produkt | N-[3-(2,2-dimethylchroman-6-ylmethylene)-2-oxo-2,3-dihydro-1H-indol-6-yl]acetamide | HCID 57040241 | 44,2% |
Reaktionsschritte
A mixture of 6-acetamido-2-oxindole (285 mg), 2,2-dimethylchroman-6-carboxaldehyde (285 mg) and piperidine (0.2 ml) was stirred at 90° C. overnight. The reaction mixture was cooled and diluted with 20 ml of water. The sticky solid which formed was filtered and chromatographed (2% ethanol in ethyl acetate) to give 240 mg (44%) of N-[3-(2,2-dimethylchroman-6-ylmethylene)-2-oxo-2,3-dihydro-1H-indol-6-yl]acetamide as an orange red solid.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patentnummer | US06855730B2 |
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| Quelldatensatz | uspto-grants-2005_02 |
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| ORD ID | ord-01a3a2ad64bf410eb46cf49e157ea541 |
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| Quellennotiz | uspto-grants-2005_02 |
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