5-Methyl-2-(pyrimidin-2-yl)benzoic acid → N,N-Dimethyl-4-{5-[(5-methyl-2-pyrimidin-2-ylphenyl)carbonyl]hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-6-(trifluoromethyl)pyrimidin-2-amine

HRID 243951

Reaktionsgleichung

Reaktionsgleichung von HRID 243951
[CH2:1]1[CH:5]2[CH2:6][NH:7][CH2:8][CH:4]2[CH2:3][N:2]1[C:9]1[CH:14]=[C:13]([C:15]([F:18])([F:17])[F:16])[N:12]=[C:11]([N:19]([CH3:21])[CH3:20])[N:10]=1.[CH3:22][C:23]1[CH:24]=[CH:25][C:26]([C:32]2[N:37]=[CH:36][CH:35]=[CH:34][N:33]=2)=[C:27]([CH:31]=1)[C:28](O)=[O:29]>>[CH3:20][N:19]([CH3:21])[C:11]1[N:10]=[C:9]([N:2]2[CH2:3][CH:4]3[CH:5]([CH2:6][N:7]([C:28]([C:27]4[CH:31]=[C:23]([CH3:22])[CH:24]=[CH:25][C:26]=4[C:32]4[N:33]=[CH:34][CH:35]=[CH:36][N:37]=4)=[O:29])[CH2:8]3)[CH2:1]2)[CH:14]=[C:13]([C:15]([F:18])([F:17])[F:16])[N:12]=1

Komponenten

3

Edukt 2

HCID 445172645-Methyl-2-(pyrimidin-2-yl)benzoic acidHCID 67116323[4-(Hexahydro-pyrrolo[3,4-c]pyrrol-2-yl)-6-trifluoromethyl-pyrimidin-2-yl]-dimethyl-amine

Produkt 1

HCID 67116603N,N-Dimethyl-4-{5-[(5-methyl-2-pyrimidin-2-ylphenyl)carbonyl]hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-6-(trifluoromethyl)pyrimidin-2-amine

Versuchsvorschrift

The title compound was prepared in a manner analogous to Example 15 utilizing Intermediate 36 and 5-methyl-2-pyrimidin-2-yl-benzoic acid. MS (ESI): mass calculated for C25H26F3N7O, 497.53; m/z found 498.0 [M+H]+. 1H NMR (400 MHz, CDCl3): 8.67 (dd, J=20.0, 4.9, 2H), 8.20 (d, J=10.1, 1H), 7.34-7.30 (m, 1H), 7.19-7.15 (m, 1H), 7.13-7.03 (m, 1H), 5.85 (br s, 1H), 3.98-2.83 (m, 16H), 2.42 (s, 3H).

Quellen und Nachweise

ORD-Eintrag
ord-8370d002d5ff404bb7e1d3430f72244d
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08653263B2

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