2-Ethoxy-1-naphthoic acid → 2-{5-[(2-Ethoxynaphthalen-1-yl)carbonyl]hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}quinoxaline

HRID 243970

Reaktionsgleichung

Reaktionsgleichung von HRID 243970
[CH2:1]1[CH:5]2[CH2:6][NH:7][CH2:8][CH:4]2[CH2:3][N:2]1[C:9]1[CH:18]=[N:17][C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[N:10]=1.[CH2:19]([O:21][C:22]1[CH:31]=[CH:30][C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[C:23]=1[C:32](O)=[O:33])[CH3:20]>>[CH2:19]([O:21][C:22]1[CH:31]=[CH:30][C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[C:23]=1[C:32]([N:7]1[CH2:6][CH:5]2[CH2:1][N:2]([C:9]3[CH:18]=[N:17][C:16]4[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=4)[N:10]=3)[CH2:3][CH:4]2[CH2:8]1)=[O:33])[CH3:20]

Komponenten

3

Edukt 2

HCID 752102-Ethoxy-1-naphthoic acidHCID 610372812-(Hexahydro-pyrrolo[3,4-c]pyrrol-2-yl)-quinoxaline2×

Produkt 1

HCID 671167122-{5-[(2-Ethoxynaphthalen-1-yl)carbonyl]hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}quinoxaline

Versuchsvorschrift

The title compound was prepared in a manner analogous to Example 15 utilizing 2-(hexahydro-pyrrolo[3,4-c]pyrrol-2-yl)-quinoxaline (Intermediate 35) and 2-ethoxy-naphthalene-1-carboxylic acid. MS (ESI): mass calculated for C27H26N4O2, 438.53; m/z found 439.2 [M+H]+. 1H NMR (400 MHz, CDCl3): 8.32 (d, J=16.4, 1H), 7.95-7.55 (m, 6H), 7.52-7.17 (m, 4H), 4.34-2.94 (m, 12H), 1.49-1.19 (m, 3H).

Quellen und Nachweise

ORD-Eintrag
ord-e22f3cc1108649799ed081c56a799bee
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08653263B2

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