2-Methoxy-4-methylbenzoic acid → (5-(4,6-Dimethylpyrimidin-2-yl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)(2-methoxy-4-methylphenyl)methanone

HRID 244026

Reaktionsgleichung

Reaktionsgleichung von HRID 244026
[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([N:9]2[CH2:16][CH:15]3[CH:11]([CH2:12][NH:13][CH2:14]3)[CH2:10]2)[N:3]=1.[CH3:17][O:18][C:19]1[CH:27]=[C:26]([CH3:28])[CH:25]=[CH:24][C:20]=1[C:21](O)=[O:22]>>[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([N:9]2[CH2:16][CH:15]3[CH2:14][N:13]([C:21]([C:20]4[CH:24]=[CH:25][C:26]([CH3:28])=[CH:27][C:19]=4[O:18][CH3:17])=[O:22])[CH2:12][CH:11]3[CH2:10]2)[N:3]=1

Komponenten

3

Edukt 2

HCID 5971642-Methoxy-4-methylbenzoic acidHCID 662108752-(4,6-Dimethylpyrimidin-2-yl)octahydropyrrolo[3,4-c]pyrrole

Produkt 1

HCID 67116335(5-(4,6-Dimethylpyrimidin-2-yl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)(2-methoxy-4-methylphenyl)methanone

Versuchsvorschrift

The title compound was prepared in a manner analogous to Example 15, utilizing Intermediate 23 and 2-methoxy-4-methylbenzoic acid. MS (ESI): mass calculated for C21H26N4O2, 366.21; m/z found 367.3 [M+H]+. 1H NMR (400 MHz, CDCl3): 7.13 (d, J=7.6, 1H), 6.77 (d, J=7.6, 1H), 6.70 (s, 1H), 6.28 (s, 1H), 4.00-3.40 (m, 11H), 3.27-2.85 (m, 3H), 2.41-2.19 (m, 9H).

Quellen und Nachweise

ORD-Eintrag
ord-4948e3e8218a4275b4791c32582e17e3
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08653263B2

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