1-(3-Aminophenyl)-n-(2-(dimethylamino)ethyl)methanesulfonamide → Surufatinib

HRID 244519Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 244519
Cl[C:2]1[N:7]=[C:6]([O:8][C:9]2[CH:10]=[C:11]3[C:15](=[CH:16][CH:17]=2)[NH:14][C:13]([CH3:18])=[CH:12]3)[CH:5]=[CH:4][N:3]=1.[NH2:19][C:20]1[CH:21]=[C:22]([CH2:26][S:27]([NH:30][CH2:31][CH2:32][N:33]([CH3:35])[CH3:34])(=[O:29])=[O:28])[CH:23]=[CH:24][CH:25]=1>>[CH3:34][N:33]([CH3:35])[CH2:32][CH2:31][NH:30][S:27]([CH2:26][C:22]1[CH:23]=[CH:24][CH:25]=[C:20]([NH:19][C:2]2[N:7]=[C:6]([O:8][C:9]3[CH:10]=[C:11]4[C:15](=[CH:16][CH:17]=3)[NH:14][C:13]([CH3:18])=[CH:12]4)[CH:5]=[CH:4][N:3]=2)[CH:21]=1)(=[O:29])=[O:28]

Komponenten

3

Edukt 2

HCID 432556941-(3-Aminophenyl)-n-(2-(dimethylamino)ethyl)methanesulfonamide2×HCID 598233595-((2-chloropyrimidin-4-yl)oxy)-2-methyl-1H-indole

Produkt 1

HCID 52920501Surufatinib

Versuchsvorschrift

The title compound of Formula A can be synthesized as the crude product of the compound of Formula A by the reaction of Compound 3 with 1-(3-aminophenyl)-N-(2-(dimethylamino)ethyl)methane-sulfonamide (Compound 4) in the presence of an acid, such as but not limited to acetic acid, formic acid, HCl, H2SO4, toluenesulfonic acid, trifluoroacetic acid, or ethanesulfonic acid acidic, and in a solvent, such as but not limited to, N,N-dimethylformamide (DMF), acetonitrile, tetrahydrofuran, ethanol, isopropanol, or toluene. The reaction can be carried out at a suitable temperature, such as a temperature ranging from 40 to 100° C.

Quellen und Nachweise

ORD-Eintrag
ord-b3a565d131b3405085d8ba46bc555a59
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08658658B2

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