Sodium Hydroxide → 4-bromo-1,3-dimethyl-1H-pyrazole-5-carboxylic acid

Temperatur

20 °C

To a solution of ethyl 4-bromo-1,3-dimethyl-1H-pyrazole-5-carboxylate (200 mg) (for example, available from Sinova) in methanol (10 ml) was added 2M sodium hydroxide (5 ml) and the mixture stirred at 20° C. for 18 h. The mixture was concentrated in vacuo and the residue taken up in water (10 ml) and acidified to pH=5 using 2M hydrochloric acid. The mixture was extracted with ethyl acetate (20 ml) dried over sodium sulphate and evaporated to give the title compound (25 mg) as a white solid.

1. concentrationThe mixture was concentrated in vacuo
2. extractionThe mixture was extracted with ethyl acetate (20 ml)
3. dry with materialdried over sodium sulphate
4. customevaporated

ORD-Eintrag

ord-892f17811ad04ed5ba0471035bfa38ca

Quelldatensatz

uspto-grants-2014_02

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08658635B2