Sodium Hydroxide → 5-(1-Methylethyl)-4-thiazolecarboxylic acid
Reaktionsgleichung
[CH3:1][CH:2]([C:4]1[S:8][CH:7]=[N:6][C:5]=1[C:9]([O:11]C)=[O:10])[CH3:3].[OH-].[Na+]>CO>[CH3:3][CH:2]([C:4]1[S:8][CH:7]=[N:6][C:5]=1[C:9]([OH:11])=[O:10])[CH3:1]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 20 °C
Versuchsvorschrift
To a solution of methyl 5-(1-methylethyl)-1,3-thiazole-4-carboxylate (1.9 g) in methanol (20 ml) was added 2M sodium hydroxide (20 ml) and the mixture stirred at 20° C. for 18 h. The solvent was removed in vacuo and the residue taken up in water (20 ml) and acidified to pH=2 using 2M hydrochloric acid. The mixture was extracted with ethyl acetate (100 ml), dried over sodium sulphate and evaporated in vacuo to give the title compound (1.7 g) as a white solid.
Aufarbeitung
- customThe solvent was removed in vacuo
- extractionThe mixture was extracted with ethyl acetate (100 ml)
- dry with materialdried over sodium sulphate
- customevaporated in vacuo
Quellen und Nachweise
- ORD-Eintrag
- ord-6b83f6d9aaa045038bfc47988077297a
- Quelldatensatz
- uspto-grants-2014_02
- Patentnummer
- US08658635B2
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