Sodium Hydroxide → HCID 58356418, Verbindung

HRID 244672Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 244672
[C:1]([C:4]1[S:8][C:7]([CH3:9])=[N:6][C:5]=1[C:10]([O:12]CC)=[O:11])(=[O:3])[CH3:2].[OH-].[Na+]>CO>[C:1]([C:4]1[S:8][C:7]([CH3:9])=[N:6][C:5]=1[C:10]([OH:12])=[O:11])(=[O:3])[CH3:2]

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 50998908Ethyl 5-acetyl-2-methyl-1,3-thiazole-4-carboxylate

Produkt 1

HCID 58356418HCID 58356418, VerbindungAusbeute 33,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Reaktionsbedingungen

Temperatur
20 °C

Versuchsvorschrift

To a solution of ethyl 5-acetyl-2-methyl-1,3-thiazole-4-carboxylate (75 mg) (available from Butt Park Ltd.) in methanol (5 ml) was added 2M sodium hydroxide (5 ml) and the mixture stirred at 20° C. for 18 h. The solvent was removed in vacuo and the mixture taken up in water (5 ml) and acidified to pH=2 using 2M hydrochloric acid then extracted with ethyl acetate (20 ml), dried over sodium sulphate and the mixture evaporated to give the title compound (22 mg) as a yellow solid.

Aufarbeitung

  1. customThe solvent was removed in vacuo
  2. extractionthen extracted with ethyl acetate (20 ml)
  3. dry with materialdried over sodium sulphate
  4. customthe mixture evaporated

Quellen und Nachweise

ORD-Eintrag
ord-8bbcfc82b78140c4bbd1c49bf688d83e
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08658635B2

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