Sodium Hydroxide → 1-(propan-2-yl)-1H-1,2,3-triazole-5-carboxylic acid

HRID 244676Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 244676
[CH3:1][CH:2]([N:4]1[C:8]([C:9]([O:11]CC)=[O:10])=[CH:7][N:6]=[N:5]1)[CH3:3].[OH-].[Na+]>CO>[CH3:3][CH:2]([N:4]1[C:8]([C:9]([OH:11])=[O:10])=[CH:7][N:6]=[N:5]1)[CH3:1]

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 58356337HCID 58356337, Verbindung

Produkt 1

HCID 583564111-(propan-2-yl)-1H-1,2,3-triazole-5-carboxylic acidAusbeute 75 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Reaktionsbedingungen

Temperatur
20 °C

Versuchsvorschrift

To a solution of ethyl 1-(1-methylethyl)-1H-1,2,3-triazole-5-carboxylate (0.315 g) in methanol (5 ml) was added sodium hydroxide (5 ml) and the mixture stirred at 20° C. for 18 h. The solvent was removed in vacuo and the residue taken up in water (5 ml) and acidified with 2M hydrochloric acid. The mixture was extracted with ethyl acetate and dried over sodium sulphate then filtered and evaporated to give the title compound (0.2 g) a white solid.

Aufarbeitung

  1. customThe solvent was removed in vacuo
  2. extractionThe mixture was extracted with ethyl acetate
  3. dry with materialdried over sodium sulphate
  4. filtrationthen filtered
  5. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-d6c5aaab542c4a5da21d5228117558be
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08658635B2

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