6-(4-Fluorophenyl)-1,3-dihydro-2H-indol-2-one → 3-{2-[6-(4-Fluorophenyl)-2-oxo-1,2-dihydroindol-3-ylidenemethyl]-5-methyl-1H-pyrrol-3-yl}propionic Acid
Reaktionsgleichung
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:16]=[C:15]3[C:11]([CH2:12][C:13](=[O:17])[NH:14]3)=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[CH:18]([C:20]1[NH:21][C:22]([CH3:30])=[CH:23][C:24]=1[CH2:25][CH2:26][C:27]([OH:29])=[O:28])=O>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:16]=[C:15]3[C:11]([C:12](=[CH:18][C:20]4[NH:21][C:22]([CH3:30])=[CH:23][C:24]=4[CH2:25][CH2:26][C:27]([OH:29])=[O:28])[C:13](=[O:17])[NH:14]3)=[CH:10][CH:9]=2)=[CH:6][CH:7]=1Komponenten
3
Versuchsvorschrift
6-(4-Fluorophenyl)-1,3-dihydroindol-2-one (70 mg, 0.31 mmol) was condensed with 3-(2-formyl-5-methyl-1H-pyrrol-3-yl)-propionic acid (56 mg) to give the title compound.
Quellen und Nachweise
- ORD-Eintrag
- ord-88c17c7d48db4061bbb4c4a807fa1b7c
- Quelldatensatz
- uspto-grants-2005_02