HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Benzyl Bromide → 8-Benzyloxy-3-methyl-1H-quinolin-2-one
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Benzyl Bromide | HCID 7498 | — |
| Edukt | Potassium Carbonate | HCID 11430 | — |
| Edukt | 3-Methyl-quinolin-2,8-diol | HCID 440986 | — |
| Lösungsmittel | Acetone | HCID 180 | — |
| Produkt | 8-Benzyloxy-3-methyl-1H-quinolin-2-one | HCID 22499223 | — |
Reaktionsschritte
Benzyl bromide (1.28 mL) is added to a suspension of potassium carbonate (2.98 g) in a solution of 8-hydroxy-3-methyl-1H-quinolin-2-one (1.26 g) in acetone (36 mL) at room temperature. The reaction mixture is refluxed for 18 hours, filtered, evaporated and purified by flash column chromatography on silica gel, eluting with 2% methanol in dichloromethane.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08658673B2 |
| Quelldatensatz | uspto-grants-2014_02 |
| ORD ID | ord-9335fb91b5654477aa63ba31b8ec8888 |
| Quellennotiz | uspto-grants-2014_02 |