HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 244769Erstellt: 25. Oktober 2026
8-benzyloxy-5-bromo-3-methyl-1H-quinolin-2-one → 8-Benzyloxy-3-methyl-5-vinyl-1H-quinolin-2-one
https://huagongshe.com/reaction/244769
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | 8-benzyloxy-5-bromo-3-methyl-1H-quinolin-2-one | HCID 22499211 | — |
| Edukt | Tri(butyl)vinyltin | HCID 53438229 | — |
| Katalysator | Tetrakis(triphenylphosphine)palladium | HCID 11979704 | — |
| Lösungsmittel | Toluene | HCID 1140 | — |
| Produkt | 8-Benzyloxy-3-methyl-5-vinyl-1H-quinolin-2-one | HCID 22499178 | — |
Reaktionsschritte
Palladium tetrakis(triphenylphosphine) (30 mg) is added to a solution of 8-benzyloxy-5-bromo-3-methyl-1H-quinolin-2-one (239 mg) and tributylvinyltin (203 μL) in toluene (7 mL) at room temperature. The reaction mixture is heated for 2 hours at 100° C., cooled to room temperature, evaporated and the product purified by flash column chromatography on silica gel, eluting with 2% ethyl acetate in dichloromethane.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patentnummer | US08658673B2 |
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| Quelldatensatz | uspto-grants-2014_02 |
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| ORD ID | ord-90cd000ba6454cce95298836ebc318df |
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| Quellennotiz | uspto-grants-2014_02 |
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