Piperidine → HCID 53888754, Verbindung

HRID 24481

Reaktionsgleichung

Reaktionsgleichung von HRID 24481
[CH3:1][N:2]([CH3:16])[S:3]([C:6]1[CH:7]=[C:8]2[C:12](=[CH:13][CH:14]=1)[NH:11][C:10](=[O:15])[CH2:9]2)(=[O:5])=[O:4].[CH3:17][C:18]1[C:26]2[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=2)[NH:20][C:19]=1[CH:27]=O.N1CCCCC1>C(O)C>[CH3:1][N:2]([CH3:16])[S:3]([C:6]1[CH:7]=[C:8]2[C:12](=[CH:13][CH:14]=1)[NH:11][C:10](=[O:15])[C:9]2=[CH:27][C:19]1[NH:20][C:21]2[C:26]([C:18]=1[CH3:17])=[CH:25][CH:24]=[CH:23][CH:22]=2)(=[O:5])=[O:4]

Komponenten

5

Edukt 3

HCID 8082PiperidineHCID 2772603-Methyl-1H-indole-2-carbaldehydeHCID 98161852-Oxo-2,3-dihydro-1H-indole-5-sulfonic acid dimethylamide

Produkt 1

HCID 53888754HCID 53888754, VerbindungAusbeute 57 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of 5-dimethylaminosulfonyl-2-oxindole (96 mg), 3-methylindole-2-carbaldehyde (56 mg) (prepared according to Synthetic Communications, 1986, 16, 1799) and piperidine (30 mg) in ethanol (1 mL) was held in a sealed tube at 90° C. overnight. The mixture was cooled to room temperature. The solid was collected by vacuum filtration, washed with cold ethanol and dried in a vacuum oven to give 76 mg (57% yield) of 3-(3-methyl-1H-indol-2-ylmethylene)-2-oxo-2,3-dihydro-1H-indole-5-sulfonic acid dimethylamide (mixture of isomers).

Aufarbeitung

  1. filtrationThe solid was collected by vacuum filtration
  2. washwashed with cold ethanol
  3. customdried in a vacuum oven

Quellen und Nachweise

ORD-Eintrag
ord-c2dc38cd3e5f41908283bfed9b702586
Quelldatensatz
uspto-grants-2005_02
Patentnummer
US06855730B2

Verknüpfte Notizen

Wird geladen…