4-Aminophenol → 2-(4-Hydroxyphenylamino)-2-methylpropanenitrile

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

A mixture of 4-aminophenol (1.09 g, 10 mmol), acetone cyanohydrin (10 ml) and MgSO4 (2 g) was heated to 80° C. and stirred for 4 h. After concentration of the medium under vacuum, compound 3a was crystallized from water (20 ml). The solid was filtered and dried to yield 2-(4-hydroxyphenylamino)-2-methylpropanenitrile, 3a (1.69 g, 9.6 mmol, 96%).

Herkunft & Nachweise