HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Acetoxyacetic acid → 2-((3-Chloropyrazin-2-yl)methylamino)-2-oxoethyl acetate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Acetoxyacetic acid | HCID 83766 | — |
| Edukt | (3-Chloropyrazin-2-yl)methanamine hydrochloride | HCID 42614233 | — |
| Produkt | 2-((3-Chloropyrazin-2-yl)methylamino)-2-oxoethyl acetate | HCID 86674647 | 90,3% |
Reaktionsschritte
According to the procedure described in example 13 step 13a acetoxyacetic acid (0.667 g) and 2-aminomethyl-3-chloropyrazine hydrochloride (content 77%; 0.81 g) gave 2-((3-chloropyrazin-2-yl)methylamino)-2-oxoethyl acetate (0.99 g) after purification by column chromatography (silica gel; gradient of dichloromethane to dichloromethane/ethyl acetate 1/1).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08658794B2 |
| Quelldatensatz | uspto-grants-2014_02 |
| ORD ID | ord-c13c3b2d8fe947b4acaf0a37564f1b7a |
| Quellennotiz | uspto-grants-2014_02 |