Trifluoroacetic acid → HCID 71280322, Verbindung

HRID 245788Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 245788
C(OC(=O)[NH:7][C@H:8]([CH:19]1[CH2:21][CH2:20]1)[C:9]([N:11]1[CH2:16][CH2:15][CH:14]([C:17]#[N:18])[CH2:13][CH2:12]1)=[O:10])(C)(C)C.[F:23][C:24]([F:29])([F:28])[C:25]([OH:27])=[O:26]>ClCCl>[F:23][C:24]([F:29])([F:28])[C:25]([OH:27])=[O:26].[NH2:7][C@H:8]([CH:19]1[CH2:21][CH2:20]1)[C:9]([N:11]1[CH2:12][CH2:13][CH:14]([C:17]#[N:18])[CH2:15][CH2:16]1)=[O:10]

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 71279447[(R)-2-(4-cyanopiperidin-1-yl)-1-cyclopropyl-2-oxo-ethyl]-carbamic acid tert-butyl ester

Produkt 1

HCID 71280322HCID 71280322, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

In a round-bottomed flask, [(R)-2-(4-cyanopiperidin-1-yl)-1-cyclopropyl-2-oxo-ethyl]-carbamic acid tert-butyl ester (2.71 g, 7.93 mmol) was dissolved in dichloromethane (50 ml). The solution was cooled to 0° C. and trifluoroacetic acid (18 ml, 234 mmol) was slowly added. After the addition was complete, the ice bath was removed and the reaction mixture was stirred at room temperature for 2 h. The reaction mixture was concentrated to provide 1-((R)-2-amino-2-cyclopropyl-acetyl)-piperidine-4-carbonitrile trifluoroacetate as a yellow oil which was used without further purification.

Aufarbeitung

  1. additionAfter the addition
  2. customthe ice bath was removed
  3. concentrationThe reaction mixture was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-132fd7700c054a4691a418451037549c
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08658646B2

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