Trifluoroacetic acid → cis-3-Amino-cyclopentanol trifluoroacetate

HRID 245887Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 245887
C(OC(=O)[NH:7][C@H:8]1[CH2:12][CH2:11][C@@H:10]([OH:13])[CH2:9]1)(C)(C)C.[F:15][C:16]([F:21])([F:20])[C:17]([OH:19])=[O:18]>ClCCl>[F:15][C:16]([F:21])([F:20])[C:17]([OH:19])=[O:18].[NH2:7][C@@H:8]1[CH2:12][CH2:11][C@H:10]([OH:13])[CH2:9]1

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 216370811,1-Dimethylethyl N-((1S,3R)-3-hydroxycyclopentyl)carbamate

Produkt 1

HCID 71280026cis-3-Amino-cyclopentanol trifluoroacetate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

In a round-bottomed flask, (cis-3-hydroxy-cyclopentyl)-carbamic acid tert-butyl ester (320 mg, 1.59 mmol) was dissolved in dichloromethane (10 ml) and trifluoroacetic acid (3.6 ml, 46.7 mmol) was slowly added. The reaction mixture was stirred at room temperature for 2 h then concentrated to afford cis-3-amino-cyclopentanol trifluoroacetate as a light yellow oil which was used without further purification.

Aufarbeitung

  1. concentrationthen concentrated

Quellen und Nachweise

ORD-Eintrag
ord-d8540ac81c3649f481372c1927db38fe
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08658646B2

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