Trifluoroacetic acid → (R)-2,2-difluoro-1-methyl-propylamine trifluoroacetate

HRID 245910Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 245910
C(OC(=O)[NH:7][C@H:8]([CH3:13])[C:9]([F:12])([F:11])[CH3:10])(C)(C)C.[F:15][C:16]([F:21])([F:20])[C:17]([OH:19])=[O:18]>ClCCl>[F:15][C:16]([F:21])([F:20])[C:17]([OH:19])=[O:18].[F:11][C:9]([F:12])([CH3:10])[C@H:8]([NH2:7])[CH3:13]

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 86677920((R)-2,2-difluoro-1-methyl-propyl)-carbamic acid tert-butyl ester

Produkt 1

HCID 86677918(R)-2,2-difluoro-1-methyl-propylamine trifluoroacetate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

In a round-bottomed flask, ((R)-2,2-difluoro-1-methyl-propyl)-carbamic acid tert-butyl ester (148 mg, 0.71 mmol) was dissolved in dichloromethane (3 ml) and trifluoroacetic acid (1.6 ml, 20.8 mmol) was slowly added. The reaction mixture was stirred at room temperature for 1.5 h then concentrated to give (R)-2,2-difluoro-1-methyl-propylamine trifluoroacetate as a light brown oil which was used without further purification.

Aufarbeitung

  1. concentrationthen concentrated

Quellen und Nachweise

ORD-Eintrag
ord-7543787c2f79473aa5d98a0a2c337a2a
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08658646B2

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