Trifluoroacetic acid → HCID 71280269, Verbindung

HRID 245933Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 245933
C(OC(=O)[NH:7][C@H:8]([CH3:19])[C:9]([F:18])([F:17])[CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)(C)(C)C.[F:21][C:22]([F:27])([F:26])[C:23]([OH:25])=[O:24]>ClCCl>[F:21][C:22]([F:27])([F:26])[C:23]([OH:25])=[O:24].[F:17][C:9]([F:18])([CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[C@H:8]([NH2:7])[CH3:19]

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 71279995((R)-2,2-difluoro-1-methyl-3-phenyl-propyl)-carbamic acid tert-butyl ester

Produkt 1

HCID 71280269HCID 71280269, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

In a round-bottomed flask, ((R)-2,2-difluoro-1-methyl-3-phenyl-propyl)-carbamic acid tert-butyl ester (92 mg, 0.32 mmol) was dissolved in dichloromethane (2 ml) and trifluoroacetic acid (0.75 ml, 9.73 mmol) was slowly added. The reaction was stirred at room temperature for 2 h then concentrated to give (R)-2,2-difluoro-1-methyl-3-phenyl-propylamine trifluoroacetate as a light brown oil which was used without further purification

Aufarbeitung

  1. concentrationthen concentrated

Quellen und Nachweise

ORD-Eintrag
ord-64c47d4dff454edaa6e4d641607f3ded
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08658646B2

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