Trifluoroacetic acid → [2-((R)-1-amino-ethyl)-oxazol-4-yl]-methanol trifluoroacetate

HRID 245940Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 245940
C(OC(=O)[NH:7][C@@H:8]([C:10]1[O:11][CH:12]=[C:13]([CH2:15][OH:16])[N:14]=1)[CH3:9])(C)(C)C.[F:18][C:19]([F:24])([F:23])[C:20]([OH:22])=[O:21]>ClCCl>[F:18][C:19]([F:24])([F:23])[C:20]([OH:22])=[O:21].[NH2:7][C@@H:8]([C:10]1[O:11][CH:12]=[C:13]([CH2:15][OH:16])[N:14]=1)[CH3:9]

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 68670262(R)-tert-butyl 1-(4-(hydroxymethyl)oxazol-2-yl)ethylcarbamate

Produkt 1

HCID 71280113[2-((R)-1-amino-ethyl)-oxazol-4-yl]-methanol trifluoroacetate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

In a round-bottomed flask, [(R)-1-(4-hydroxymethyl-oxazol-2-yl)-ethyl]-carbamic acid tert-butyl ester (137 mg, 0.51 mmol) was dissolved in dichloromethane (3 ml) and trifluoroacetic acid (1.2 ml, 15.6 mmol) was slowly added. The reaction was stirred at room temperature for 1.5 h then concentrated to afford [2-((R)-1-amino-ethyl)-oxazol-4-yl]-methanol trifluoroacetate as a brown oil which was used without further purification.

Aufarbeitung

  1. concentrationthen concentrated

Quellen und Nachweise

ORD-Eintrag
ord-c2524aa9dd504d68bc535e9ec978dcc4
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08658646B2

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