Trifluoroacetic acid → (R)-3-amino-1-pyrrolidin-1-yl-butan-1-one trifluoroacetate

HRID 245987

Reaktionsgleichung

Reaktionsgleichung von HRID 245987
C(OC(=O)[NH:7][C@H:8]([CH3:17])[CH2:9][C:10](=[O:16])[N:11]1[CH2:15][CH2:14][CH2:13][CH2:12]1)(C)(C)C.[F:19][C:20]([F:25])([F:24])[C:21]([OH:23])=[O:22]>C(Cl)Cl>[F:19][C:20]([F:25])([F:24])[C:21]([OH:23])=[O:22].[NH2:7][C@H:8]([CH3:17])[CH2:9][C:10]([N:11]1[CH2:15][CH2:14][CH2:13][CH2:12]1)=[O:16]

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 71280091((R)-1-methyl-3-oxo-3-pyrrolidin-1-yl-propyl)-carbamic acid tert-butyl ester

Produkt 1

HCID 71280224(R)-3-amino-1-pyrrolidin-1-yl-butan-1-one trifluoroacetate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of ((R)-1-methyl-3-oxo-3-pyrrolidin-1-yl-propyl)-carbamic acid tert-butyl ester (crude from step 1, 189 mg, 0.74 mmol) in CH2Cl2 (5 mL) was added trifluoroacetic acid (2.0 mL, 27.0 mmol). The reaction mixture was stirred at room temperature for 2 h then concentrated to give (R)-3-amino-1-pyrrolidin-1-yl-butan-1-one trifluoroacetate as a pale yellow oil which was used without further purification.

Aufarbeitung

  1. concentrationthen concentrated

Quellen und Nachweise

ORD-Eintrag
ord-5f47dedac97a4f4d8af977687f9660a6
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08658646B2

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