Hydrochloric Acid → (R)-1-(4-trifluoromethylpyridin-2-yl)-ethylamine dihydrochloride

HRID 246015Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 246015
[F:1][C:2]([F:19])([F:18])[C:3]1[CH:8]=[CH:7][N:6]=[C:5]([C@H:9]([NH:11][S@@](C(C)(C)C)=O)[CH3:10])[CH:4]=1.[ClH:20].O1CCOCC1>CO>[ClH:20].[ClH:20].[F:18][C:2]([F:1])([F:19])[C:3]1[CH:8]=[CH:7][N:6]=[C:5]([C@H:9]([NH2:11])[CH3:10])[CH:4]=1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 71288258(R)-2-methyl-propane-2-sulfinic acid [(R)-1-(4-trifluoromethyl-pyridin-2-yl)-ethyl]-amide

Produkt 1

HCID 86677935(R)-1-(4-trifluoromethylpyridin-2-yl)-ethylamine dihydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of (R)-2-methyl-propane-2-sulfinic acid [(R)-1-(4-trifluoromethyl-pyridin-2-yl)-ethyl]-amide (225 mg, 0.76 mmol) in MeOH (4 mL) was added 4.0 M hydrogen chloride in dioxane (0.48 mL, 1.9 mmol). The reaction mixture was stirred at room temperature for 30 min then concentrated and dried under high vacuum to afford 225 mg of (R)-1-(4-trifluoromethyl-pyridin-2-yl)-ethylamine dihydrochloride as a viscous colorless oil which was used without further purification.

Aufarbeitung

  1. concentrationthen concentrated
  2. customdried under high vacuum

Quellen und Nachweise

ORD-Eintrag
ord-fd2010156f404f32b97ee332e31151cc
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08658646B2

Notizen zur Reaktion

Wird geladen…