Trifluoroacetic acid → 1-((R)-2-amino-propionyl)-azetidine-3-carbonitrile trifluoroacetate

HRID 246101Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 246101
C(OC(=O)[NH:7][C@H:8]([CH3:17])[C:9]([N:11]1[CH2:14][CH:13]([C:15]#[N:16])[CH2:12]1)=[O:10])(C)(C)C.[F:19][C:20]([F:25])([F:24])[C:21]([OH:23])=[O:22]>ClCCl>[F:19][C:20]([F:25])([F:24])[C:21]([OH:23])=[O:22].[NH2:7][C@H:8]([CH3:17])[C:9]([N:11]1[CH2:12][CH:13]([C:15]#[N:16])[CH2:14]1)=[O:10]

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 67386290HCID 67386290, Verbindung

Produkt 1

HCID 673864061-((R)-2-amino-propionyl)-azetidine-3-carbonitrile trifluoroacetate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

[(R)-2-(3-cyanoazetidin-1-yl)-1-methyl-2-oxo-ethyl]-carbamic acid tert-butyl ester (47 mg, 0.185 mmol) was dissolved in dichloromethane (1 ml) and cooled in an ice bath. Trifluoroacetic acid (0.5 ml) was slowly added and the reaction was stirred at room temperature for 2 h then evaporated and dried under high vacuum to afford 1-((R)-2-amino-propionyl)-azetidine-3-carbonitrile trifluoroacetate which was used without further purification.

Aufarbeitung

  1. temperaturecooled in an ice bath
  2. customthen evaporated
  3. customdried under high vacuum

Quellen und Nachweise

ORD-Eintrag
ord-75e169a338254f73aa75681bbc65fe9a
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08658646B2

Notizen zur Reaktion

Wird geladen…