Sodium hydride → 2-[6-Chloro-4-fluoro-1-(2-morpholin-4-yl-ethyl)-1H-indazol-3-yl]-5-(2-trimethylsilanylethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid isopropylamide

Beteiligte Stoffe

Reaktionsschritte

2-(6-Chloro-4-fluoro-1H-indazol-3-yl)-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid isopropylamide (77 mg, 0.15 mmol) was dissolved in DMF (2.5 ml) and cooled in an ice bath. Sodium hydride (60% dispersion, 8 mg, 0.20 mmol) was carefully added. The mixture was stirred for 15 min then additional sodium hydride (60% dispersion, 10 mg, 0.25 mmol) and 4-(2-bromoethyl)morpholine hydrochloride (42 mg, 0.18 mmol) were added. The reaction was warmed to room temperature and stirred overnight. Water, sodium bicarbonate solution and ethyl acetate were added to the reaction. The layers were separated and the aqueous layer was extracted three times with ethyl acetate. The combined organic layers were washed water and sodium chloride solution and dried over sodium sulfate. After evaporation, the residue was purified by silica gel chromatography (methanol/dichloromethane) to give 66 mg (70%) of 2-[6-chloro-4-fluoro-1-(2-morpholin-4-yl-ethyl)-1H-indazol-3-yl]-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid isopropylamide.

Herkunft & Nachweise