Trifluoroacetic acid → (R)-1-methyl-2-pyrazol-1-yl-ethylamine trifluoroacetate

HRID 246121Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 246121
C(OC(=O)[NH:7][C@H:8]([CH3:15])[CH2:9][N:10]1[CH:14]=[CH:13][CH:12]=[N:11]1)(C)(C)C.[F:17][C:18]([F:23])([F:22])[C:19]([OH:21])=[O:20]>ClCCl>[F:17][C:18]([F:23])([F:22])[C:19]([OH:21])=[O:20].[CH3:15][C@@H:8]([NH2:7])[CH2:9][N:10]1[CH:14]=[CH:13][CH:12]=[N:11]1

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 71279609((R)-1-methyl-2-pyrazol-1-yl-ethyl)-carbamic acid tert-butyl ester

Produkt 1

HCID 71279935(R)-1-methyl-2-pyrazol-1-yl-ethylamine trifluoroacetate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

((R)-1-Methyl-2-pyrazol-1-yl-ethyl)-carbamic acid tert-butyl ester (49 mg, 0.22 mmol) was dissolved in dichloromethane (2.4 ml) and cooled in an ice bath. Trifluoroacetic acid (1.2 ml) was slowly added and the reaction was stirred at room temperature for 2 h then evaporated and dried under high vacuum to afford (R)-1-methyl-2-pyrazol-1-yl-ethylamine trifluoroacetate which was used without further purification.

Aufarbeitung

  1. temperaturecooled in an ice bath
  2. customthen evaporated
  3. customdried under high vacuum

Quellen und Nachweise

ORD-Eintrag
ord-4d94d1181e9045979f536c89b3a589b0
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08658646B2

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