Trifluoroacetic acid → (R)-3-amino-2-methyl-propionitrile trifluoroacetate
Reaktionsgleichung
C(OC(=O)[NH:7][CH2:8][C@H:9]([C:11]#[N:12])[CH3:10])(C)(C)C.[F:14][C:15]([F:20])([F:19])[C:16]([OH:18])=[O:17]>ClCCl>[F:14][C:15]([F:20])([F:19])[C:16]([OH:18])=[O:17].[NH2:12][CH2:11][C@@H:9]([CH3:10])[C:8]#[N:7]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
((R)-2-Cyano-2-methyl-ethyl)-carbamic acid tert-butyl ester (42 mg, 0.23 mmol) was dissolved in dichloromethane (1.2 ml) and cooled in an ice bath. Trifluoroacetic acid (0.7 ml) was slowly added and the reaction was stirred at room temperature for 3 h then evaporated and dried under high vacuum to afford (R)-3-amino-2-methyl-propionitrile trifluoroacetate which was used without further purification.
Aufarbeitung
- temperaturecooled in an ice bath
- customthen evaporated
- customdried under high vacuum
Quellen und Nachweise
- ORD-Eintrag
- ord-18b095b4312b412a98cb285f2a192129
- Quelldatensatz
- uspto-grants-2014_02
- Patentnummer
- US08658646B2
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